It is generally not recommended to take Advil (ibuprofen) during pregnancy , especially after 20 weeks of gestation. Taking ibuprofen in early pregnancy may increase the risk of birth defects, miscarriage, and pregnancy complications. During the second trimester, while sometimes considered safer than in the first or third trimesters, it is still advised to avoid ibuprofen. After 20 weeks, taking ibuprofen can lead to serious fetal issues including poor kidney function, reduced amniotic fluid, and heart problems from premature closure of the ductus arteriosus, which is a vital blood vessel in the baby’s heart. In the third trimester, the risks are even more severe and include potential death of the baby in extreme cases. Acetaminophen (Tylenol) is usually recommended as a safer alternative for pain relief during pregnancy, but it should also be used under medical advice. In summary, the safest course is to avoid Advil during pregnancy and consult a healthcare provider for alternative pain management options.