It is generally safe to take ibuprofen after drinking alcohol if done in moderation and with caution. Experts recommend waiting at least 4 to 6 hours after consuming alcohol before taking ibuprofen to reduce risks. Some sources suggest waiting even longer—up to 10 hours or a full day—because alcohol can remain in the body for up to 24 hours, and combining it with ibuprofen can increase risks like gastrointestinal bleeding, stomach irritation, liver and kidney damage. People with preexisting conditions such as liver or kidney disease, gastrointestinal issues, or a history of stomach bleeding should be especially cautious or avoid combining ibuprofen and alcohol altogether. If ibuprofen is taken after moderate alcohol consumption, it is best to take it with food and stay hydrated to minimize side effects. In summary, waiting several hours (at least 4-6, preferably up to 10 or 24 hours) after drinking alcohol before taking ibuprofen is advisable for safety. If there are health concerns or heavy drinking, consult a healthcare professional before combining them.