Voltaren gel works by delivering diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), through the skin to the site of pain. Diclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2) which are involved in the production of prostaglandins—chemicals that cause inflammation, pain, and swelling. By reducing prostaglandin synthesis in peripheral tissues, Voltaren gel helps reduce pain and inflammation locally where applied, providing targeted relief with less systemic exposure compared to oral medications.
Detailed Mechanism
- Diclofenac blocks COX-1 and COX-2 enzymes, reducing prostaglandins, which sensitize nerves to pain and mediate inflammation.
- The gel's emulgel formulation allows it to penetrate the skin and accumulate in tissues like the synovial tissue around joints, producing a sustained analgesic effect.
- This local action helps reduce pain and swelling in joints and muscles without widespread effects in the rest of the body.
Use and Benefits
- Applied directly to the affected area, Voltaren gel provides pain relief for conditions such as arthritis, tendonitis, muscle injuries, and other inflammatory disorders.
- It acts relatively quickly and targets the site of pain, reducing the risk of systemic side effects typical of oral NSAIDs.
In summary, Voltaren gel works through the topical delivery of diclofenac to inhibit inflammation-causing prostaglandins locally, thus reducing pain and swelling at the site of application.
