Dulcolax works at different speeds depending on the form taken. Suppositories provide the fastest relief within 15 to 60 minutes. Liquid and soft chew forms generally work in about 30 minutes to 6 hours. Tablets usually take longer, around 6 to 12 hours to work. Stool softeners in Dulcolax may take 12 hours to up to 3 days to soften stool without causing a bowel movement. Staying hydrated is important for effectiveness, especially with certain forms.