Linzess (linaclotide) typically begins relieving constipation within about 1 week of starting daily treatment, though some people notice improvements within 24 hours and others may take up to 2 weeks for full relief. Abdominal symptoms like bloating and abdominal pain often improve more gradually, with many people experiencing broader relief over 4 to 12 weeks, and maximum benefit sometimes reported around 6 to 9 weeks of consistent use. Individual response can vary based on condition (e.g., chronic constipation vs IBS-C), dosage, and adherence to taking it on an empty stomach as directed. If you’re not seeing any improvement after a couple of weeks, or if you experience worsening symptoms or side effects, consult your healthcare provider promptly.
