The maximum recommended daily dose of Tylenol (acetaminophen) for most healthy adults is 4,000 milligrams (mg) in 24 hours. Taking more than this can increase the risk of liver damage. Typically, this equates to no more than eight 500 mg tablets or six 650 mg tablets in a day. The dose should be spaced out, usually no more than 1,000 mg every 4 to 6 hours. For certain people such as older adults, those with liver problems, or frequent alcohol users, a lower maximum dose might be advised. It is important never to exceed the recommended dose on the packaging and to consider all sources of acetaminophen in combination products to avoid accidental overdose. If there is any doubt or underlying health conditions, consulting a healthcare provider is recommended. Immediate medical help is necessary if an overdose is suspected, even if no symptoms appear initially.
