No painkiller is completely “safe” to take with alcohol, and combining the two is generally discouraged because of risks to the liver, stomach, kidneys, and breathing.
Biggest dangers
Mixing alcohol with acetaminophen (paracetamol/Tylenol) can significantly increase the risk of liver damage, especially with repeated use, high doses, or heavy drinking. Nonsteroidal anti‑inflammatory drugs (NSAIDs) like ibuprofen and naproxen can irritate the stomach and, with alcohol, raise the risk of ulcers and stomach bleeding.
Prescription painkillers that contain opioids (such as codeine, hydrocodone, oxycodone, tramadol, morphine) plus alcohol can dangerously slow breathing and cause extreme drowsiness and overdose, so alcohol should be avoided completely with these.
When it may be less risky
Occasional use of over‑the‑counter doses of ibuprofen, naproxen, or acetaminophen after only a small amount of alcohol is sometimes considered low risk for otherwise healthy adults, but the combination is still not recommended because of the potential for serious side effects over time. If you have liver disease, stomach ulcers, kidney problems, take other medicines, or drink regularly, even small combined amounts can be unsafe and need medical advice.
Practical advice
- If you have been drinking, the safest option is to avoid painkillers until the alcohol is out of your system and use rest, fluids, and food instead if possible.
- Never mix alcohol with any opioid or prescription‑strength painkiller, and do not exceed the labeled dose of any over‑the‑counter pain reliever.
- If you are in significant pain, drink regularly, or have any medical conditions, contact a doctor or urgent care for specific advice rather than choosing a painkiller on your own.
If you describe how much you drank, your health conditions, and what painkillers you have at home, more tailored (but still general) guidance can be given, though it cannot replace personal medical care.
