Derek Shepherd, the character from Grey's Anatomy, dies in Season 11, Episode 21, titled "How to Save a Life." He is involved in a devastating car crash, and although he initially helps other accident victims, Derek suffers a brain injury that is not diagnosed quickly enough at a hospital lacking a trauma center. Complications from the injury lead to him being declared brain dead, and Meredith Grey consents to remove him from life support. This event occurs while Meredith is pregnant with their third child.
The timeline in the show suggests Derek's death episode aired around 2015, with the in-show date of death being around late March or early April 2015, often cited as March 26, 2015.
The death marked a significant turning point in the show, deeply affecting the storyline and characters, particularly Meredith and Derek's family.
