The first NFL game of the regular season for 2025 is scheduled for Thursday, September 4, 2025. The game will feature the Dallas Cowboys playing against the Philadelphia Eagles in Philadelphia as part of the NFL Kickoff Game. The kickoff time is 8:20 p.m. ET and it will be broadcast on NBC.
Additionally, historically, the NFL Kickoff Game is typically held on the Thursday following Labor Day in early September, marking the official start of the NFL regular season.
For historical context, the first-ever NFL game dates back to October 3, 1920, when the Dayton Triangles hosted the Columbus Panhandles at Triangle Park, Dayton, Ohio.
