Karen Reed is a former financial analyst and professor who was a murder suspect in the death of her boyfriend, John O'Keefe, a Boston police officer. After more than three years as a suspect and facing two criminal jury trials, she was acquitted of second-degree murder charges in June 2025 but was convicted of a lesser offense. Despite her acquittal, she still faces a civil lawsuit related to O'Keefe's death. Her case garnered significant media attention and public scrutiny, with some supporters believing she was framed, while others believed she was responsible for O'Keefe's death. The case involved allegations of police misconduct and was marked by intense legal battles and public interest. Reed also has disclosed health issues including Crohn's disease and multiple sclerosis.
Additionally, there is another individual named Karen Reid who is an American politician and served as a Republican member of the New Hampshire House of Representatives, but this person is unrelated to the criminal case mentioned above.