The killers in the "Scream" movie franchise are known for wearing the Ghostface mask, with multiple characters revealed as killers in different films:
- In the original 1996 "Scream," the killers were Billy Loomis and Stu Macher. Billy's motive was linked to his mother leaving him after discovering an affair between Sidney's mother and his father. Billy and Stu killed Sidney's mother and framed another character while targeting Sidney and her friends.
- In "Scream 2," the main killer was Mickey Altieri, a college friend of Sidney's, who kills multiple people on campus.
- In "Scream 5" (2022), the killers were Richie Kirsch, Sam Carpenter's boyfriend, and Amber Freeman, Tara's friend. They were obsessed fans of the in-universe horror franchise "Stab" and aimed to inspire a real-life continuation of the series. They killed people related to the original killings and ultimately killed Dewey Riley.
- In "Scream 6" (2023-2024), there were multiple killers, including Jason Carvey and Greg, Detective Wayne Bailey, and his children Quinn Bailey and Ethan Landry. Their motives tied back to family and revenge related to the previous killers, particularly Richie Kirsch. Bailey is considered the mastermind behind the killings in this installment.
Thus, the killers have varied by movie, often involving multiple characters working together, all under the Ghostface identity.