John Reardon left the show Hudson & Rex primarily due to his health battle with tonsil cancer. During the production of season 7, he was diagnosed with this serious illness, which forced him to take a leave of absence for treatment. His character was written out temporarily as being away on a mission while he underwent treatment. Although John Reardon was medically cleared to return and is now cancer-free, when he recovered, the show continued without him by introducing a new character, Detective Mark, effectively ending Reardon's role on the series. There has been speculation and rumors about whether he was fired or if it was a mutual decision, but no official confirmation was provided. It is clear, however, that his health issues and subsequent recovery played a significant role in his departure, with also possible factors like creative and production decisions influencing the outcome. Fans and insiders indicate that it was a difficult and sensitive situation, with John Reardon wanting to return but not being fully welcomed back to the show in the same capacity. In summary, John Reardon's departure was mainly health-driven, compounded by production choices during and after his treatment for tonsil cancer.