After taking mifepristone alone, bleeding usually does not start immediately. Some people may experience light spotting or bleeding, but significant bleeding typically begins after taking the second medication, misoprostol. Bleeding generally starts within four hours after taking misoprostol, though it can sometimes start later. The bleeding after misoprostol is often heavier than a normal period and may include clots. The light spotting or bleeding that can occur after mifepristone alone usually happens within 1 to 2 days after taking it, but for many, the major bleeding begins only after misoprostol is taken.