Possums (or opossums) are generally not dangerous to humans. They are shy, non-aggressive animals that prefer to avoid confrontation, often using defense mechanisms like playing dead or hissing rather than biting or scratching. While possums can bite or scratch if they feel threatened or cornered, such incidents are rare. The primary concern is the potential transmission of diseases such as leptospirosis, tuberculosis, spotted fever, tularemia, toxoplasmosis, and others through their urine, feces, or parasites like ticks and fleas. It is wise to avoid direct contact with possums or their droppings to minimize any health risks. They are more beneficial than harmful since they help control pests like ticks. Proper precautions such as avoiding handling and keeping living areas sealed can prevent problems related to possums.