Wolf spiders are venomous but not poisonous to humans. Their venom is used to subdue prey and is generally not harmful to humans. While a wolf spider bite can cause pain, swelling, redness, and itching, it is not lethal or highly dangerous. Serious allergic reactions are rare but possible. These spiders are not aggressive and typically bite only when threatened. Overall, wolf spider bites are mild and usually comparable to a bee sting in terms of pain and effects.