Cats cannot have Down syndrome because it is a condition caused by an extra copy of chromosome 21, which is unique to humans who have 23 pairs of chromosomes. Cats have only 19 pairs of chromosomes, so the genetic basis for Down syndrome does not exist in cats. However, some cats may display physical or behavioral traits that resemble those seen in humans with Down syndrome. These traits may be due to other genetic mutations, congenital defects, infections during pregnancy, exposure to toxins, or neurological conditions distinct from Down syndrome. Cats showing such symptoms might have facial abnormalities, developmental delays, or behavioral differences caused by their own unique genetic or health issues, but this is not Down syndrome as defined in humans. It is important for a veterinarian to evaluate cats with these symptoms to diagnose and manage the actual underlying condition. In summary, while cats cannot have Down syndrome, they can have disorders that may mimic some of the syndrome’s physical or behavioral traits.