Yes, it is generally safe to take DayQuil and ibuprofen together as they do not have direct interactions. DayQuil contains acetaminophen (Tylenol), dextromethorphan, and phenylephrine, while ibuprofen is an NSAID. Taking these two can help relieve symptoms more effectively because they work through different mechanisms. However, caution is advised since both acetaminophen (in DayQuil) and ibuprofen can have side effects, particularly on the liver, kidneys, stomach, and cardiovascular system, especially for people with underlying health conditions like heart disease, kidney problems, or those taking blood thinners like warfarin. It is usually recommended to space the medications a few hours apart for better symptom management, and you should avoid exceeding the recommended doses of either drug. Consulting a healthcare provider before combining these is the safest approach, especially for seniors or those with health risks.