It is generally not recommended to take Excedrin while pregnant, especially during the third trimester. Excedrin contains aspirin, which can be harmful to the unborn baby and increase the risk of complications such as premature closure of the ductus arteriosus and excessive bleeding during delivery. Full- dose aspirin is usually avoided after the 20th week of pregnancy, and if needed, its use should be limited and monitored by a healthcare provider. Excedrin also contains caffeine, which should be limited during pregnancy due to potential risks to the baby. It is important to consult a healthcare provider before taking Excedrin or any medication containing aspirin or caffeine during pregnancy. Acetaminophen, another ingredient in Excedrin, is considered safer to use during pregnancy but should also be taken under medical advice. In summary, avoid Excedrin in pregnancy unless specifically advised by a doctor, especially in the later stages of pregnancy. Alternatives like acetaminophen may be safer options for pain relief during pregnancy.