Yes, you can take nail polish on a plane. For carry-on luggage, nail polish is considered a liquid and must comply with the TSA's 3-1-1 rule: each container must be 3.4 ounces (100 milliliters) or less, and all liquid containers must fit within a single quart-sized, clear, resealable plastic bag. Nail polish can also be packed in checked luggage, where there are generally fewer restrictions. However, since nail polish contains flammable solvents, it should be packed carefully to avoid leaks or damage during the flight.
It is not recommended to use nail polish on the plane due to the smell and the risk of spills caused by turbulence. For larger quantities or bigger bottles, packing nail polish in checked luggage is safer. To avoid breakage or spills, it is advisable to pack the bottles in padded cases or wrap them in bubble wrap inside resealable plastic bags.