Sudafed, which contains pseudoephedrine, is generally not recommended during the first trimester of pregnancy due to a possible increased risk of certain birth defects such as gastroschisis and other rare defects, although the overall risk is considered very small. Many experts and organizations, including the American College of Obstetricians and Gynecologists (ACOG), advise avoiding pseudoephedrine in the first 3 months of pregnancy. However, it may be considered safer for use in the second and third trimesters if the benefits outweigh the risks, but always under medical supervision. Additionally, pseudoephedrine can raise blood pressure, so those with hypertension should be cautious and consult a healthcare provider before use during pregnancy. Breastfeeding women are also advised to consult their healthcare providers before taking pseudoephedrine, as it may reduce milk supply and pass into breast milk in small amounts.
