can i take zofran while pregnant

Zofran (ondansetron) is commonly prescribed off-label to treat nausea and vomiting during pregnancy, especially for severe cases like hyperemesis gravidarum. It is generally considered to be low risk and is classified as pregnancy category B by the FDA, meaning there is no conclusive evidence of harm to humans though large-scale definitive studies are still lacking. Most studies show it is safe when used in pregnancy, particularly during the first trimester when morning sickness is most common. However, some studies suggest a very slight increased risk of cleft palate and heart defects in babies exposed to Zofran during pregnancy, with these risks being very small (less than 3 in 10,000 births). The FDA has also issued warnings about potential maternal heart risks, such as irregular heartbeats. Due to these concerns, Zofran is usually recommended when other safer alternatives have not worked and under medical supervision. Common side effects in pregnancy include constipation, fatigue, and headaches. Doctors often recommend trying natural remedies or other medications first before prescribing Zofran. In summary, Zofran can be taken while pregnant under doctor guidance, especially if nausea is severe, but it is important to discuss risks and alternatives with a healthcare provider.