It is generally safe to drink alcohol in moderation while taking nitrofurantoin, as there are no known direct interactions between the two. However, alcohol is a bladder irritant and can worsen urinary tract infection (UTI) symptoms, potentially making side effects of nitrofurantoin like nausea, dizziness, or bladder irritation worse. It is recommended to avoid or minimize alcohol intake during treatment and for at least 48 hours after finishing nitrofurantoin to ensure the best effectiveness and recovery. People with certain health conditions or alcohol dependency are advised to avoid alcohol completely while on this antibiotic. Consulting a healthcare provider for personalized advice is always best.