It is generally safe to drink a small amount of alcohol (such as one glass of wine, beer, or spirits) while taking ibuprofen for most people. However, combining alcohol and ibuprofen can increase the risk of side effects, particularly stomach and digestive tract irritation, which can lead to ulcers and bleeding. Additionally, both alcohol and ibuprofen can affect the kidneys, and this combination may increase the risk of kidney damage, especially in people with preexisting conditions like liver or kidney disease, high blood pressure, or heart failure. If consuming alcohol while taking ibuprofen, it is advisable to do so in moderation and avoid excessive drinking. It's also recommended to take ibuprofen with food to reduce stomach irritation. Those with underlying health issues or who consume alcohol heavily should avoid mixing the two due to higher risks of complications such as gastric bleeding, kidney damage, and other serious side effects. Experts also suggest waiting at least 4 to 6 hours after drinking alcohol before taking ibuprofen to reduce risks. If ibuprofen has been taken, it is best to avoid alcohol for several hours (about 10 hours) to minimize adverse effects. In summary, occasional moderate alcohol consumption with ibuprofen is usually okay for healthy individuals, but caution and moderation are key, and it should be avoided in those with certain health conditions or heavy alcohol use.