It is generally advised to avoid drinking alcohol while taking Aleve (naproxen), as the combination can increase the risk of serious gastrointestinal issues such as stomach bleeding and ulcers. Although some sources indicate that moderate alcohol consumption may be acceptable, the potential for harm rises significantly with heavier drinking or prolonged use of Aleve.
Gastrointestinal Risks
Aleve, like other NSAIDs, reduces the production of prostaglandins that protect the stomach lining. Alcohol also irritates the stomach, and when combined, their effects can compound, leading to gastritis, ulcers, or even life-threatening gastrointestinal bleeding. The risk is especially elevated in individuals over 60 or those with a history of stomach ulcers.
Liver and Kidney Effects
Both Aleve and alcohol are processed by the liver and can strain this organ when used together, potentially leading to liver damage over time. Additionally, Aleve reduces blood flow to the kidneys, while alcohol causes dehydration through its diuretic effect, increasing the risk of acute kidney injury or long-term kidney dysfunction.
Duration of Risk
Aleve is a long-acting NSAID with a half-life of 12–17 hours, meaning it can remain in the system for up to three days. For safety, alcohol should be avoided during this entire period, especially in individuals with underlying health conditions or those taking other medications [
