It is generally not recommended to drink alcohol while taking azithromycin. Alcohol can increase the risk of side effects such as nausea, vomiting, diarrhea, headache, and liver damage. It can also worsen azithromycin's gastrointestinal side effects and potentially reduce the antibiotic's effectiveness in treating infections. For safety, it is advised to avoid alcohol during the course of azithromycin treatment and for at least 72 hours after finishing the medication. If azithromycin makes you feel dizzy, it is especially important to avoid alcohol since it can worsen dizziness. While moderate alcohol consumption does not directly reduce the drug's effectiveness, combining the two can put extra strain on the liver and immune system and may prolong recovery from infection. In summary, to minimize side effects and ensure the antibiotic works well, abstain from drinking alcohol during azithromycin treatment and for about three days after completing it. Consult a healthcare provider for personalized advice if needed.