It is generally recommended to avoid drinking alcohol while taking Tylenol (acetaminophen) because both substances are processed by the liver and can put additional stress on it. Taking Tylenol after drinking alcohol, especially in excessive or frequent amounts, increases the risk of liver damage or acetaminophen toxicity. However, using Tylenol in moderation and drinking alcohol in moderation (no more than three drinks per day) is usually considered relatively safe for most people without existing liver issues. If alcohol consumption is heavy or frequent, it is best to avoid Tylenol altogether or consult a healthcare provider for advice. Waiting 12 to 24 hours after drinking before taking Tylenol is safer if alcohol was consumed in larger amounts. Signs of liver damage from combining Tylenol and alcohol include yellowing of skin or eyes, abdominal swelling, nausea, and confusion. For those who drink regularly, speaking to a healthcare professional before using acetaminophen is advised. Alternative pain relievers such as NSAIDs may be considered but come with their own risks, especially if alcohol is involved.
