Yes, paracetamol can be taken on an empty stomach and it is considered safe to do so. Unlike some painkillers such as ibuprofen and aspirin, paracetamol does not irritate the stomach lining, so it does not require being taken with food. In fact, taking paracetamol on an empty stomach may sometimes allow it to work faster. However, if someone has a sensitive stomach, they might experience mild stomach irritation, so taking it with food could be a safer option in such cases. It is important to follow the recommended dose and not exceed the daily limits to avoid risks like liver damage.