Yes, Tylenol (acetaminophen) can be taken on an empty stomach safely. It does not require food for protection because it is gentler on the stomach than nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, which can cause stomach irritation or ulcers. Taking Tylenol with a full glass of water is recommended, and some people may even experience faster absorption when taken without food. However, a few individuals might experience mild stomach upset or nausea, in which case taking it with food could help.
