The main cast of The Morning Show includes:
- Jennifer Aniston as Alexandra "Alex" Levy, co-host of the morning show
- Reese Witherspoon as Bradley Jackson, former co-host and news anchor
- Billy Crudup as Cory Ellison, CEO of the network UBA
- Mark Duplass as Charlie "Chip" Black, executive producer of the show
- Gugu Mbatha-Raw as Hannah Shoenfeld (season 1), talent booker
- Néstor Carbonell as Yanko Flores, meteorologist
- Karen Pittman as Mia Jordan, producer
- Bel Powley as Claire Conway (seasons 1–2), production assistant
- Desean Terry as Daniel Henderson (seasons 1–2), weekend co-host
- Jack Davenport as Jason Craig (season 1), Alex's ex-husband
- Steve Carell as Mitch Kessler (seasons 1–2), former co-host
- Greta Lee as Stella Bak (season 2–present), President of news division
- Ruairi O'Connor as Ty Fitzgerald (season 2), social media expert
- Julianna Margulies as Laura Peterson (seasons 2–3), co-host and former anchor
- Nicole Beharie as Christine Hunter (season 3), new co-host
- Jon Hamm as Paul Marks (season 3), tech billionaire
- Marion Cotillard as Celine Dumont (season 4)
- Jeremy Irons as Martin Levy (season 4), Alex's father
- Aaron Pierre as Miles (season 4)
- William Jackson Harper as Ben (season 4), Head of Sports
- Boyd Holbrook as Brodie (season 4), podcaster and talk show host
There are also notable guest stars such as Mindy Kaling, Martin Short, Will Arnett, and others across the seasons
. This ensemble cast portrays the complex dynamics behind a network morning news program, with the series tackling topical issues including the #MeToo movement, the COVID-19 pandemic, and political events
