The cost of Zepbound without insurance is approximately $1,086.37 per month for the pen injector supply. However, there are more affordable options available directly through Eli Lilly's LillyDirect program, where the price can range from $349 for the 2.5 mg vial (starter dose) to $499 for higher doses per month. There is also a savings card that can reduce the cost to about $650 per month for those without insurance but not eligible for other programs. The vial form is only available without insurance and at a lower cost than the pen injector.