Ketamine can be dangerous, with risks including addiction, physical harm, mental health complications, and overdose. Regular use can lead to tolerance and dependency, and overdose can cause life-threatening issues such as respiratory distress, unconsciousness, and cardiac arrest. Long-term effects include bladder and urinary tract damage, cognitive impairments, and worsening of pre-existing mental health disorders. Ketamine use also increases the risk of accidents due to impaired motor function and judgment. While it is considered safe as a medicine in controlled therapeutic settings, recreational use is associated with significant risks and fatalities, often in combination with other substances. Ketamine overdose signs include inability to move, muscle rigidity, convulsions, unconsciousness, and high blood pressure, and such overdose can be fatal. Psychological effects include hallucinations and a dissociative state called a "K-hole," which can be terrifying. Ketamine- related deaths have increased, especially linked to polydrug use. Immediate medical attention is critical in cases of overdose.