James Gandolfini died of a heart attack while on vacation in Rome, Italy, at the age of 51. He was found unconscious in his hotel room bathroom by his son and was pronounced dead shortly after being rushed to the hospital. An autopsy confirmed that his death was caused by a massive heart attack, with no foul play or substance abuse involved. Gandolfini's sudden death shocked fans worldwide, as he was well-known for his role as Tony Soprano in "The Sopranos" TV series.