Derrick Henry is one of the fastest running backs in the NFL, despite his large size. According to NFL Next Gen Stats, he has reached top speeds of about 21.29 mph during game situations, notably on an 87-yard touchdown run. He hit a peak speed of 21.72 mph on an 81-yard run as well. These speeds rank among the fastest recorded by any NFL ball carrier in recent years. He has also surpassed the 20 mph mark multiple times while carrying the ball, a rare feat given his weight of around 247-250 pounds. At the 2016 NFL Combine, Henry recorded a 40-yard dash time of 4.54 seconds, which is remarkable for his size. In summary, Derrick Henry runs at speeds exceeding 21 mph on the field, showcasing a unique combination of power and elite speed for his size.