You typically need to fast for 8 to 12 hours before blood work. This fasting means no food or drinks except plain water during that period. The exact fasting duration can vary depending on the specific blood test, but the general guideline is to fast overnight and have your blood drawn in the morning for accurate results. Water intake is encouraged to keep you hydrated, but avoid any other beverages, food, smoking, gum, or exercise that could affect test results. Some tests, like glucose and triglycerides, particularly require fasting, while others may not. Always follow the specific instructions given by your healthcare provider for best accuracy.