Endone, which contains the opioid oxycodone, typically lasts for about 4 to 6 hours when taken as an immediate-release tablet. The pain relief from Endone usually begins within 10 to 15 minutes, peaks around 30 to 60 minutes, and persists for 3 to 6 hours. The usual dose is one tablet every six hours, following a doctor's instructions. If taken as a slow-release form (which is different from Endone standard tablets), effects can last up to 12 hours.