Amoxicillin typically starts working on a toothache caused by infection within 24 to 72 hours, with some initial relief of pain and swelling often noticed within the first one to two days. However, completely clearing the infection usually takes about 7 to 10 days, and it is important to finish the entire prescribed course to fully eradicate the bacteria and prevent recurrence or resistance. If symptoms persist or worsen beyond this time frame, consulting a healthcare provider is recommended.
