Cymbalta (duloxetine) typically begins to help with mood and anxiety symptoms within about 2 to 4 weeks, with many people noticing some improvement earlier. For full benefit, it can take 6 to 8 weeks or longer in some individuals, and the exact timeline can vary based on dose, condition being treated (depression, anxiety, fibromyalgia, etc.), other medications, and individual factors. If symptoms haven’t improved after 6 to 8 weeks, or if side effects become troublesome, it’s important to check in with your clinician before making any changes to the dose or stopping the medication. Key points to discuss with your clinician:
- Your current symptoms and any changes since starting duloxetine
- Any side effects you’re experiencing (e.g., nausea, sleep changes, dry mouth, sexual side effects)
- Whether you’re taking other medicines or supplements that could interact
- The possibility of adjusting the dose or length of treatment before evaluating effectiveness
If you’re experiencing severe side effects, signs of an allergic reaction, or thoughts of self-harm, seek urgent medical attention.
