Fluconazole typically begins to work within 24 to 72 hours after taking it. For simple infections such as vaginal yeast infections, symptom relief can often start within 24 to 48 hours. However, more severe or systemic infections may take days to weeks to show improvement. Although symptom relief may begin quickly, complete resolution of the infection can take one to two weeks or longer depending on the type and severity of the infection. It is important to take the medication exactly as prescribed for the best results.
