Accutane (isotretinoin) typically takes about 4 to 6 months to fully work and clear acne. Most people start noticing some improvement within the first couple of months, but it is common for acne to initially worsen before getting better. The initial phase may include skin dryness, chapped lips, and acne flares. By months 4 to 6, acne is significantly reduced or cleared. For many, the results are long-lasting, though some may require a second course of treatment. The early effects can begin within 1 to 2 months, sometimes even as soon as 7 to 10 days, but substantial clearing takes longer. The treatment duration and speed of results depend on factors like dosage, acne severity, and individual response to the medication. Dermatologists closely monitor treatment due to potential side effects and the need for careful dosage management.