how long does it take for clotrimazole tablet to dissolve

7 hours ago 4
how long does it take for clotrimazole tablet to dissolve

Clotrimazole tablets, particularly vaginal tablets, typically take about 5 to 8 minutes to completely disintegrate under test conditions. In dissolution studies using 0.1 M HCl (simulating acidic conditions), disintegration occurred at about 5 ± 0.4 minutes, and in acetate buffer pH 5.2 containing 1% SDS (a surfactant environment), it took about 8 ± 0.6 minutes for complete disintegration. Dissolution profiles show significant drug release (over 80%) within 20 to 30 minutes in these conditions, depending on the method used for testing.

For vaginal use, clotrimazole tablets dissolve in the vaginal moisture, and it's common to notice some white residue. Complete dissolution in the vaginal environment can vary, but vaginal suppositories generally take 15 to 30 minutes to dissolve and absorb, and clotrimazole vaginal tablets may behave similarly, although some pieces might remain if vaginal dryness is present.

In summary:

  • In laboratory dissolution conditions, clotrimazole tablets disintegrate in about 5-8 minutes.
  • In actual vaginal use, dissolution and absorption typically occur within 15 to 30 minutes, but some residue may remain depending on moisture levels.