Diflucan (fluconazole) typically starts working within 24 to 72 hours for simple fungal infections like vaginal yeast infections. Many people notice symptom relief such as reduced itching or discharge within the first 1 to 2 days. However, it can take longer—up to 1 to 2 weeks or more—to fully clear the infection, especially for more severe or systemic fungal infections. Completing the full prescribed course is crucial for effective treatment and to prevent recurrence.
