Doxycycline typically starts working within 24 to 72 hours (1 to 3 days) after beginning treatment. You may notice symptom improvement such as reduced pain, fever, or inflammation within this timeframe. However, the full course of treatment usually lasts 1 to 2 weeks or longer, depending on the infection type and severity, to completely clear the infection. For some conditions like acne or rosacea, noticeable improvement may take a few weeks, with full effects possibly requiring several months. It is important to complete the entire prescribed course even if symptoms improve earlier to prevent antibiotic resistance and ensure full recovery.
