Motrin (ibuprofen) typically begins to relieve pain and fever within about 30 minutes after a dose, with peak levels in the bloodstream around 1–2 hours. Full relief, especially for inflammation, may take longer and can vary by person and the underlying condition. Most people experience noticeable improvement within 1–2 hours, and the effect generally lasts about 6–8 hours, depending on the dose and formulation. Taking ibuprofen with food can help reduce stomach upset, but it may slightly delay absorption. If you’re treating a chronic inflammatory condition or if your symptoms persist beyond a couple of days, or if you have any health conditions or take other medications, consult a healthcare professional for guidance.
