Pepto-Bismol typically takes about 30 to 60 minutes to start working and provide relief from symptoms such as nausea, heartburn, indigestion, upset stomach, and diarrhea. If symptoms persist after the first dose, another dose can be taken after 30 to 60 minutes, but one should not exceed more than 8 doses in 24 hours. It is effective because its active ingredient, bismuth subsalicylate, acts as an antacid, antibacterial, and antidiarrheal by coating the stomach and intestines, reducing inflammation, and neutralizing excess stomach acid. For best results, avoid alcohol and spicy, acidic, or fatty foods while taking Pepto-Bismol, and drink plenty of water to stay hydrated. If symptoms last more than two days or worsen, consult a doctor. This medication is generally safe for short-term use in adults and children 12 years and older, but it is not recommended for prolonged use beyond two days without medical advice.