how long does it take for prednisone to work

Prednisone usually starts to work very quickly, often within 1 to 2 hours of taking the first dose. However, the full effects may take a few days (1 to 4 days) depending on the condition being treated and the dose prescribed. Immediate-release forms absorb within 2 hours, while delayed-release forms can take about 6 hours to start working. Symptom improvement, such as reduced inflammation or relief from allergic reactions, typically becomes noticeable in this timeframe. Prednisone is often taken with food to minimize stomach upset and should be tapered off under medical supervision if used for more than two weeks to avoid withdrawal symptoms.