Tirzepatide begins to suppress appetite quite quickly, with many people noticing reduced hunger within the first 24 hours to 1-2 weeks after their first injection. The medication works by activating GIP and GLP-1 receptors, which slow gastric emptying and promote feelings of fullness, leading to appetite suppression
. However, the appetite-suppressing effects become more pronounced and consistent over time, typically within 4 to 8 weeks as the dosage is gradually increased. Most patients experience well-established appetite suppression and initial weight loss by about 2 to 4 weeks, with more significant effects and weight loss occurring after 8 to 12 weeks of consistent use
. In summary:
- Initial appetite suppression can start within 24 hours to 1-2 weeks.
- Noticeable and sustained appetite suppression usually develops over 4 to 8 weeks.
- Full benefits, including significant appetite suppression and weight loss, are generally seen after 2 to 3 months of consistent treatment.
This timeline can vary by individual depending on dosage, personal health factors, and adherence to treatment
. Thus, while some feel appetite changes quickly, it typically takes several weeks for tirzepatide to fully suppress appetite and support weight loss effectively.
