Antibiotics for a urinary tract infection (UTI) typically start to work within 24 to 48 hours of starting the medication. Most people begin to notice relief from symptoms such as burning and urgency during urination within this time frame. However, it is crucial to complete the full course of antibiotics as prescribed, which can range from three days to two weeks depending on the severity of the infection, to fully clear the infection and prevent relapse. For uncomplicated bladder infections, symptom relief often begins in 1 to 2 days, with some antibiotics like ciprofloxacin potentially providing improvement within 6 hours. Kidney infections or more severe UTIs may take longer to respond to antibiotics, sometimes several days to a week or more. Drinking plenty of water and following treatment instructions are important to support recovery.