Wegovy starts working inside the body within a few days of the first injection, but it takes about 16 to 20 weeks to build up to the maintenance dose. Noticeable changes in appetite may take several days to weeks, and initial weight loss of about 2% to 3% of body weight can be seen in the first month. More significant weight loss typically occurs over several months, often around 5-10% by 12 weeks, and up to 15-20% after about a year when combined with lifestyle changes. The gradual increase in dosage during the first few months helps minimize side effects and optimize weight loss results.
