Zoloft (sertraline) typically takes about 4 to 6 weeks to show its full therapeutic effects. However, some individuals may notice small improvements, such as better sleep or reduced irritability, within the first 1 to 2 weeks. For anxiety, minor relief from physical symptoms may appear within a few weeks, but significant results usually take around 4 to 6 weeks as well. In some cases, depending on the condition being treated (like OCD or PTSD), it may take up to 12 weeks for the full effect. It's important to take Zoloft daily as prescribed and consult a doctor if no progress is noticed after 6 to 8 weeks. Side effects experienced at the beginning are generally temporary and subside with time.
