NyQuil generally takes about 30 minutes to begin working after taking it, though some people may feel effects as soon as 15 minutes depending on dosage and metabolism. It typically provides symptom relief for about 4 to 6 hours, with the drowsiness effect lasting up to 8 hours. NyQuil's active ingredients include acetaminophen (pain reliever and fever reducer), dextromethorphan (cough suppressant), and doxylamine succinate (antihistamine that causes drowsiness).
